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The Journal of Internal Korean Medicine 2006;27(2): 305-315. |
| 淸血湯과 加味淸血湯이 肥滿에 미치는 影響 |
| 김만호, 조충식, 김철중 |
| 대전대학교 한의과대학 신계내과학교실 |
| The Effects of Cheunghyeoltang(CHT) and Gami-Cheunghyeoltang(GCHT) on the Obesity |
| Man-ho Kim, Chung-Sik Cho, Chul-Jung Kim |
| Deptartment of Internal Medicine, College of Oriental Medicine, Daejeon University |
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Received: April 15, 2006, Accepted: June 15, 2006, Published online: June 30, 2006. |
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| ABSTRACT |
Objectuves :
The purpose of this study was to investigate the effects of Cheunghyeoltang(CHT) and Gami-Cheunghyeoltang(GCHT) on the obesity in rats.
Methods :
After we divided rats into four different groups, we provided to normal group general diet and distilled water, to control group high fat diet and distilled water, to CHT group high fat diet and CHT and to GCHT group with high fat diet and GCHT for 9 weeks. Afterward we check the change of body weight, the concentration of AST, ALT, total cholesterol, HDL-cholesterol, LDL-cholesterol, the Atherogenic index and the gene expression of leptin in rats.
Results:
The increase of body weight were suppressed significantly in the CHT group and GCHT group in comparision with control group, the serum ALT showedsignificant decrease in the GCHT group in comparison with control group, the serum total cholesterol showed significant decrease in the CHT and GCHT group in comparison with control group, the atherogenic index(AI) showed significant decrease in the GCHT group in comparison with control group and the serum leptin showed increase of gene expression in the GCHT group in comparison with control group.
Conclusions:
According to the experimental results, it is suggested that CHT is effective to the suppression of body weight's increase, the improvement of hyperlipidemia and the activation of leptin's gene expression, GCHT is effective to the suppression of body weight's increase, the improvement of hyperlipidemia, the decrease of arteriosclerosis and the activation of leptin's gene expression. Therefore CHT and GCHT seem to be applicable to obesity, arteriosclerosis and hyperlipidemia in clinical practice. |
| Key words:
Cheunghyeoltang(Qingxue-tang), Gami-Cheunghyeoltang(Jiaweiqingxue-tang), obesity |
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