| 消積健脾丸顆粒이 흰쥐의 胃運動性에 미치는 영향 |
| 홍종희, 윤상협, 김진성, 류봉하 |
| 경희대학교 한의과대학 비계내과 교실 |
| Effect of Sojukgunbihwan granule on Gastric Motility in Rats |
| Jong-hee Hong, Sang-hyub Yoon, Jin-sung Kim, Bong-ha Ryu |
| 3rd Dept. of Internal Medicine, College of Oriental Medicine, Kyung Hee University |
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Received: February 11, 2006, Accepted: March 3, 2006, Published online: March 30, 2006. |
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| ABSTRACT |
Background & Objective :
The herbal medicine Sojukgunbihwan granule has been used for the treatment of functional dyspepsia, generally categorized as a gastric dysmotility disease. However, its mechanisms are not yet well known. Therefore, the effects of Sojukgunbihwan granules on gastric motility in rats was investigated.
Methods :
The myoelectrical activity of the gastric smooth muscle was recorded by a bipolar electrode placed at the gastric antrum of rats. The contractile waves were measured for 30 minutes before and after intragastric administration of each solution(normal saline, Pyungwisan 40㎎/㎏, Sojukgunbihwan granules 60㎎/㎏) and expressed as the motility index. Gastric emptying was measured by the number of glass beads expelled from the stomach(containing one hundred 1㎜ glass beads) within an hour after glass beads and test drugs(normal saline, Pyungwisan 40㎎/㎏, Pyungwisan 120㎎/㎏, Sojukgunbihwan granules 60㎎/㎏, Sojukgunbihwan granules 180㎎/㎏) were administered. In another series of experiments to evaluate the mechanisms of Sojukgunbihwan granules under delayed conditions, the rats were treated with atropine sulfate(1㎎/㎏, s.c.), cisplatin(10㎎/㎏, i.p.), and NAME(NG-nitro-L-arginine methyl ester, 75㎎/㎏, s.c.) respectively.
Results:
Intragastric administration of Sojukgunbihwan granules increased the myoelectrical activity significantly, gastric motility index rose 25%, and gastric emptying of glass beads was significantly enhanced over a period of 60minutes. Under the delayed gastric emptying induced by atropine sulfate, cisplatin, and NAME, Sojukgunbihwan granules aggravated gastric emptying in the atropine sulfate(5.71±3.45 vs 3.71±4.42) and cisplatin(13.86±3.53 vs 5.14±5.05, p<0.01) treated groups, but enhanced gastric emptying in the NAME treated group(5.00±3.21 vs 11.71±5.65, p<0.05).
Conclusions:
Results suggest that Sojukgunbihwan granules stimulate gastric motility through cholinergic and 5-hydroxytryptamine 3 receptors. Results are indicative of Sojukgunbihwan as an especially effective remedy in dysmotility-like functional dyspepsia with impaired reservoir functions such as gastric adaptive relaxation. |
| Key words:
Sojukgunbihwan granule, gastric motility, gastric myoelectrical activity, gastric emptying. |
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