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The Journal of Internal Korean Medicine 2007;28(3): 510-518. |
| 자음양영탕이 Streptozotocin(STZ)로 유발된 생쥐의 고혈당에 미치는 影響 |
| 이형호, 이영수 |
| 동신대학교 한의과대학 내과학 교실 |
| Effect of Jaeumyangyung-tang on the Hyperglycemic Mice Induced with Streptozotocin |
| Hyung-ho Lee, Young-soo Lee |
| Department of internal, College of Oriental Medicine, Dong-shin University |
| Correspondence |
Hyung-ho Lee ,Tel: 062-350-7283, Fax: 062-366-1882, Email: yhh43@hanmail.net
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Published online: September 30, 2007. |
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| ABSTRACT |
Objectives:
The aim of this study was to investigate the effect of Jaeumyangyung-tang (滋陰養榮湯(JY), JA-0.65g/kg; JB-1.3g/kg) on hyperglycemic mice induced with streptozotocin(STZ).
Methods :
The experiment operated for 6 weeks. The rats were divided into 3 groups : diabetic group(control group), diabetic group treated with JA(0.65g/kg) for 6 weeks, and diabetic group treated with Jb(1.3g/kg) for 6 weeks.
Results:
In the STZ-induced diabetic group, blood glucose levels significantly increased as well as the loss of body weight. The levels of serum glucose decreased significantly (p<0.05 or p<0.01) in the JA and JB groups compared with the control. According to a tolerance test, intraperitoneal glucose was ameliorated in the JA and JB groups. The blood urea nitrogen (BUN) and creatinine levels slightly decreased. Histologic analyses of the pancreases revealed that the β-cells on Langerhans’ islets were destroyed by STZ, but the β-cell mass was larger in the JY than in the control mice.
Conclusions:
These results indicate that JY can exert beneficial effects on diabetes, preservation of in vivo β-cell function and regeneration of β-cell dysfunction by STZ. |
| Key words:
Jaeumyangyung-tang (滋陰養榮湯), Streptozotocin(STZ), Diabetes) |
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