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The Journal of Internal Korean Medicine > Volume 29(1); 2008 > Article
Original Article
The Journal of Internal Korean Medicine 2008;29(1): 265-277.
흰쥐의 肝損傷에 대한 加味愈肝湯의 肝 保護效果
정희1, 고호연2, 하유군3, 여현수2, 백종우3, 고성규1, 박종형3, 전찬용2, 강재춘4
1경희대학교 한의과대학 예방의학교실
2경원대학교 한의과대학 내과학교실
3경원대학교 인천한방병원
4강재춘한의원
Protective Effects of Gami Yugan-tang on Liver Damage in Rats
Hee Jung1, Ho-yeon Go2, Yu-chun Hsia3, Hyun-soo Yeo2, Jong-woo Baik3, Seung-gyu Ko1, Jong-hyung Park3, Chan-yong Jun2, Jea-chun Kang4
1Department of Preventive Medicine, College of Oriental medicine, Kyunghee University
2Department of Internal Medicine, College of Oriental medicine, Kyungwon University
3Department of Internal Medicine, Kyungwon University In-cheon Oriental Medical Hospital
4Kang Jea-Chun Oriental Medicine Clinic
Correspondence  Jea-chun Kang ,Tel: 02-458-2272, Fax: 02-458-2273, 
  Published online: March 30, 2008.
ABSTRACT
In order to investigate the protective effects of Gami Yugan-tang on liver damage in rats induced by CCl4 and d-galactosamine, the serum transaminase(ALT & AST), alkaline phosphatase(ALP), lactic dehydrogenase(LDH), superoxide dismutase(SOD), catalase, glutathione S-transferase(GST), glutathione peroxidase(GPX) for enzyme activities, and lipid peroxidation were measured. All animals were divided into 4 groups: normal group (untreated), control group (treated with 0.9% saline solution), sample Ⅰ group (treated with 740㎎/㎏ Gami Yugan-tang), and sample Ⅱ group (treated with 1,480㎎/ ㎏ Gami Yugan-tang).
The results were as follows :
1. The results of liver damage in rats induced by CCl4 : The protective effects of ALT were displayed in sample Ⅰ and sample Ⅱ, and AST, ALP, LDH, SOD, catalase, GST, GPX, and lipid peroxidation were noted in sample Ⅱ group. It showed slight necrosis of hepatic cell and pathologic changes, for example, inflammatory cells infiltration were improved in sample Ⅱ group compared to the control group.
2. The results of liver damage in rats induced by d-galactosamine : The inhibitory effects of AST, ALT, LDH, and ALP activities were noted in both sample Ⅰ and sample Ⅱ groups.
The findings from this experiment suggests that Gami Yugan-tang has protective effects against liver damage in rats induced by CCl4 and d-galactosamine.
Key words: Gami Yugan-tang, CCl4, d-Galactosamine
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