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The Journal of Internal Korean Medicine > Volume 29(2); 2008 > Article
The Journal of Internal Korean Medicine 2008;29(2): 385-400.
消炎整腸湯이 DSS로 誘發된 생쥐의 궤양성 대장염에 미치는 影響
송영근, 류봉하, 윤성우
경희대학교 한의과대학 비계내과학교실
The Effects of Soyumjungjang-tang on DSS-Induced Ulcerative Colitis in Mouse
Young-guen Song, Bong-ha Ryu, Seong-woo Yoon
3rd Department of Internal Medicine, College of Oriental Medicine, Kyunghee University
Correspondence  Bong-ha Ryu ,Tel: 02-958-9137, Fax: 02-958-9136, Email: rbongh@khu.ac.kr
  Published online: June 30, 2008.
ABSTRACT
Objectives:
This study was carried out to investigate the effects of Soyumjungjang-tang(SJT) on the experimental ulcerative colitis induced by dextran sulfate sodium(DSS) in mice.

Methods :
Ulcerative colitis was induced through supplying 4% DSS solution as the drinking water for 7 days in 6-week-old male ICR mice. The colitic mice were divided into three groups: the sample groups were orally administered SJT in doses of 25mg/kg(S25 group) or 100mg/kg(S100 group) once a day for 10 days, from 3 days before starting drinking the DSS solution, and the control(C) group was administered normal saline instead of SJT. The DSS solution or SJT was not administered to the normal(N) group. The length of colon, histologic finding, the activities of myeloperoxidase(MPO) and alkaline phosphatase(AP), and the expressions of IL-1β, IL-6, COX-2, NF-κB, and IκB in colonic mucosa was checked using immunoblot, ELISA, etc. The activities of chondroitinase, tryptophanase, β-glucuronidase and β-glucosidase in stool were also measured.

Results:
The length of colon shortened, histologic finding deteriorated, the activities of MPO, AP, chondroitinase, tryptophanase, β-glucuronidase and β-glucosidase, and the expressions of IL-1β, IL-6, COX-2, NF-κB increased, and the expression of I-κB decreased in the C group. All measures, except NF-κB, were restored in S25 group, but some measures deteriorated more in the S100 group than in the C group.

Conclusions:
According to the above results, it is supposed that SJT has a potential therapeutic effect on ulcerative colitis.
Key words: Soyumjungjang-tang, Ulcerative Colitis, COX-2, IL-1β, IL-6, IκB
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