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The Journal of Internal Korean Medicine > Volume 29(2); 2008 > Article
The Journal of Internal Korean Medicine 2008;29(2): 490-499.
천화분 추출물이 혈관신생 및 암세포성장에 미치는 영향
김동우, 이종훈, 유화승, 조정효, 이연월, 손창규, 조종관
대전대학교 동서암센터
Effects of Trichosanthes kirilowii Extract against Angiogenesis and Various Tumor Cells' Growth
Dong-woo Kim, Jong-hoon Lee, Hwa-seung Yoo, Jung-hyo Cho, Yeon-weol Lee, Chang-gue Son, Chong-kwan Cho
Department of East-West Cancer Center, Oriental Hospital of Daejeon University
Correspondence  Chong-kwan Cho ,Tel: 82-42-470-9132, Fax: 82-42-470-9006, Email: altyhs@dju.ac.kr
  Published online: June 30, 2008.
ABSTRACT
Objectives:
This study was aimed to elucidate the effects of Trichosanthes kirilowii extract (TKE) on the angiogenesis and growth of tumor cells.

Methods :
Tube formation assay was performed by using human umbilical vein endothelial cells (HUVEC), and anchorage dependent colony assay was performed by using B16-F10 melanoma, Hep G2 and HT1080, CT-26 and SNU-1 cells.

Results:
For HUVEC, TKE at a level of more than 100 ㎍/㎖ suppresses cell growth. For HUVEC at 100 ㎍/㎖ and greater TKE density, the formation of tubes was suppressed in a dose-dependant manner. TKE controls the colony formations of B16-F10 melanoma cells, CT 26 cells, and Hep G2 cells, and its effect is proportional to density. In HT1080 cells and SNU-1 cells, formation is suppressed regardless of density.

Conclusions:
From these results, it could be concluded that TKE has significant properties on anti-angiogenesis and growth inhibiting of tumor cells. It is suggested that TKE will be a good candidate for new drugs or therapeutics for anti-angiogenesis.
Key words: Trichosanthes kirilowii Extract(TKE), Anti-angiogenesis, Cancer
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