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The Journal of Internal Korean Medicine > Volume 29(3); 2008 > Article
The Journal of Internal Korean Medicine 2008;29(3): 608-620.
총명탕, 원지, 석창포가 베타아밀로이드로 유발된 학습과 기억장애에 미치는 영향
박은경1, 심은섭2, 정혁상2, 손낙원1, 손영주3
1경희대학교 동서의학대학원
2경희대학교 한의과대학 한의학연구소
3상지대학교 한의과대학
Effects of Chongmyung-tang, Polygalae Radix and Acori Graminei Rhizoma on Aβ Toxicity and Memory Dysfunction in Mice
Eun-kyung Park1, Eun-shep Shim2, Hyuk-sang Jung2, Nak-won Sohn1, Young-joo Sohn3
1Graduate School of East-West Medicine, Kyung Hee University
2Institute of Oriental Medicine, College of Oriental Medicine, Kyung Hee University
3College of Oriental Medicine, Sangji University
Correspondence  Young-joo Sohn ,Tel: 033-741-9303, Fax: 033-732-2124, Email: q701@chollian.net
  Published online: September 30, 2008.
ABSTRACT
Objectives:
This study investigated the protective effects of the water extracts of Chongmyung-tang, Polygalae Radix, and Acori Graminei Rhizoma in an in vivo Alzheimer's disease (AD) mouse model.

Methods :
Memory impairment was induced by an intraventricular injection of Aβ25-35 peptides and subsequently Chongmyung-tang, Polygalae Radix, or Acori Graminei Rhizoma extract were administered orally for 14 days.

Results:
In the water maze task, Chongmyung-tang, Polygalae Radix, and Acori Graminei Rhizoma extracts improved learning ability during the acquisition period and significantly increased memory scores during the retention period versus Aβ -injected controls. Furthermore, the toxicity of Aβ25-35 on hippocampus was assessed immunohistochemically (Tau, MAP2, TUNEL, Bax) and by in vitro study. Chongmyung-tang, Polygalae Radix, and Acori Graminei Rhizoma demonstrated significant neuroprotective effects against oxidative damage and apoptotic cell death of hippocampal neurons damaged by Aβ 25-35.

Conclusions:
These results suggested that Chongmyung-tang, Polygalae Radix and Acori Graminei Rhizoma extract improve memory impairment and reduce Alzheimer’s dementia via anti-apoptotic effects and by modulating the expressions of Tau and MAP2 protein in the hippocampus.
Key words: Chongmyung-tang, Aβ25-35, water maze, Tau, MAP2
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