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The Journal of Internal Korean Medicine > Volume 33(3); 2012 > Article
The Journal of Internal Korean Medicine 2012;33(3): 306-316.
상엽(桑葉)의 고지방식이 유도 비만 쥐에 대한 조직학적 및 혈청학적 항비만 효과 연구
이지숙1, 노현인1, 윤다래1, 이서라1, 류재환2
1경희대학교 한의과대학 내과학교실
2동서의학대학원 동서의학과
Histological and Serological anti-Obesity Effect of Mori Folium in Obesity Induced SD Rat by High Fat Diet
Jee-sook Lee1, Hyun-in Noh1, Da-rae Yoon1, Seo-ra Yi1, Jae-hwan Lew2
1Dept. of Oriental Internal Medicine, College of Oriental Medicine, Kyung-Hee University
2East-west medicine department, Graduate school of east-west medical science, Kyung-Hee University
Correspondence  Jae-hwan Lew ,Tel: 02-958-1812, Fax: 02-958-9212, Email: intmed@khu.ac.kr
  Published online: September 30, 2012.
ABSTRACT
Objectives:
Mori Folium is used for hyperlipidemia or diabetes. The study was designed to test the anti-obesity effect of Mori Folium on body weight, hepatic fat accumulation and serum lipid level.

Methods :
The extract from Mori Folium was made by the pharmacy department of Kyung-hee oriental medical hospital. Normal diet, high-fat diet, 30% reduced diet and Mori Folium groups were set. The normal group was administered normal rat food, but the other three groups were administered high fat food. We measured body weight once a week. After 3 weeks experiment, hepatic lipid accumulations were measured. Also we compared serum lipid levels among the 4 groups after 3 weeks.

Results:
Mori Folium had no effect on body weight, but the 30% reduced diet had an inhibitory effect on body weight gain. Mori Folium had more inhibitory effect on hepatic fat accumulation than a 30% reduced diet. Mori Folium also has more inhibitory effect on serum triglyceride than 30% reduced diet.

Conclusions:
Mori Folium has anti-obesity effect on hepatic lipid accumulaion and serum triglyceride level in high fat diet induced rats.
Key words: Mori Folium, high-fat diet, body weight, hepatic lipid accumulation, triglyceride.
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