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The Journal of Internal Korean Medicine > Volume 33(4); 2012 > Article
The Journal of Internal Korean Medicine 2012;33(4): 418-428.
오적산의 추출 용매 차이에 따른 염증 및 염증 관련 질환에 대한 효능 비교
유새롬, 정수진, 김예지, 임혜선, 진성은, 전우영, 신인식, 신나라, 김성실, 김정훈, 하혜경, 이미영, 김온순, 서창섭, 신현규
한국한의학연구원 한약기초연구그룹
Effects of water and ethanol extracts from Ojeok-san on inflammation and its related diseases
Sae-rom Yoo, Soo-jin Jeong, Ye-ji Kim, Hye-sun Lim, Seong-eun Jin, Woo-young Jeon, In-sik Shin, Na-ra Shin, Seong-sil Kim, Jung-hoon Kim, Hye-kyung Ha, Mee-young Lee, Ohn-soon Kim, Chang-seob Seo, Hyeun-kyoo Shin
Basic Herbal Medicine Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine
Correspondence  Hyeun-kyoo Shin ,Tel: +82-42-868-9464, Fax: +82-42-864-2120, Email: hkshin@kiom.re.kr
  Published online: December 30, 2012.
Ojeok-san, a traditional herbal formula, has been used for the treatment of cold illness and its related symptoms such as headache, nausea and indigestion. This study was performed to compare effects of water (OJSW) and 70% ethanol extracts (OJSE) of Ojeok-san on inflammation and its related diseases atopy, asthma and obesity in vitro.

Methods :
We performed HPLC to investigate contents of index components of OJSW and OJSE. We investigated the effects of OJSW and OJSE with an in vitro model, using 5 cell lines, specifically RAW 264. 7, HaCaT, MC/9, BEAS-2B and 3T3-L1.

HPLC analysis displayed that the contents of index components were higher in OJSE than OJSW. In lipopolysaccharide (LPS)-treated RAW 264.7 macrophages, OJSE significantly inhibited productions of interleukin (IL)-6, nitrite and prostaglandin E2 (PEG2). In TNF-α/IFN-γ-treated HaCaT keratinocytes, OJSE significantly lowered levels of macrophage-derived chemokine (MDC) as well as regulated and normal T cell expressed and secreted (RANTES). OJSE also had a protective effect on inflammatory response by decreasing RANTES secretion in TNF-α-stimulated BEAS-2B cells.

We conclude that OJSE could be more appropriate to enhance the biological activities against inflammation and its related diseases, and could be applied as a bioactive material for developing the potent anti-inflammatory agents.
Key words: Ojeok-san (Wuji-san), water extract, 70% ethanol extract, anti-inflammation, anti-allergic disease
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