| 단삼투여가 고지방식이로 유발된 비만형 당뇨병 동물모델에 미치는 영향 |
| 최선욱1, 김동훈1, 최승범1, 박근희2, 김용성1 |
1동신대학교 한의과대학 내과학교실
2동신대학교 한의과대학 사상의학교실 |
| The Effects of Salvia miltiorrhiza on High Fat Diet-induced Obese Diabetic Mouse Model |
| Seon-wook Choi1, Dong-hoon Kim1, Seung-bum Choi1, Geun-hee Park2, Young-seung Kim1 |
1Dept. of internal Medicine of Oriental Medicine, Dong-Shin University
2Dept. of Sasang Constitutional Medicine of Oriental Medicine, Dong-Shin University |
| Correspondence |
Young-seung Kim ,Tel: 061-280-7902, Fax: 061-330-7788, Email: underlo@hanmail.net
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Published online: December 30, 2012. |
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| ABSTRACT |
Objectives:
Obesity is an important cause of diabetes, and lipotoxicity causes insulin resistance. In this study, we investigated the effects of Salvia miltiorrhiza on high fat diet-induced obese type 2 diabetic mouse models.
Methods :
Diabetes was induced in ICR male mouse (23∼25 g) with Surwit's high fat, high sucrose diet. Mice were divided into 4 groups (n=10) of normal, control, Salvia miltiorrhiza, and metformin. After 8 weeks, body weight, OGTT, fructosamine, lipid profile, serum level of adiponectin and leptin, epididymal fat pad, liver weight and epididymal adipocyte size were measured.
Results:
Salvia miltiorrhiza significantly reduced oral glucose tolerance levels, fructosamine serum level, epididymal fat weight, and epididymal adipocyte size. Salvia miltiorrhiza also increased HDL-cholesterol, adiponectin and leptin serum levels.
Conclusions:
These results show that Salvia miltiorrhiza improves insulin resistance. Therefore we suggest that Salvia miltiorrhiza would be an effective treatment for obese type 2 diabetic patients. |
| Key words:
Salvia miltiorrhiza, insulin resistance, type 2 diabetes, obesity |
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