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The Journal of Internal Korean Medicine 2013;34(1): 100-111. |
| 蘇木이 산화적 손상 및 Raw 264.7 cell과 HUVEC에서의 염증 유관 인자에 미치는 영향 |
| 강성순, 김명신, 조재준, 최성안, 양의호, 전상윤, 최창원, 홍석 |
| 동신대학교 한의과대학 내과학교실 |
| The impact of Caesalpinia Sappan L. on Oxidative Damage and Inflammatory Relevant Factor in RAW 264.7 Cells and HUVEC |
| Seong-sun Kang, Myung-sin Kim, Jae-jun Jo, Seong-an Choi, Eui-ho Yang, Sang-yun Jeon, Chang-won Choi, Soek Hong |
| Dept. of Internal Medicine, College of Oriental Medicine, Dong-Shin University |
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Published online: March 30, 2013. |
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| ABSTRACT |
Objectives:
This study investigated the impact of Caesalpinia sappan L. on oxidative damage and inflammatory relevant factor
in RAW 264.7 cells and human umbilical vein endothelial cells (HUVEC).
Objectives:
This study investigated the impact of Caesalpinia sappan L. on oxidative damage and inflammatory relevant factor in RAW 264.7 cells and human umbilical vein endothelial cells (HUVEC).
Methods :
We determined whether fractionated EtOH extracts of Caesalpinia sappan L. (CSL) inhibit free radical generation such as 2,2-diphenyl-1-picrylhydrazyl (DPPH), reactive oxygen species (ROS) and nitric oxide (NO) and pro-inflammatory cytokines in lipopolysaccharide (LPS)-treated RAW 264.7 cells and HUVEC.
Result:
1. DPPH removal capacity was increased by CSL. 2. LPS-induced ROS, and NO inhibitory capacity were increased by CSL. 3. LPS-induced cell death of Raw 264.7 cells was decreased by CSL. 4. The amount of cytokine generation in Raw 264.7 cell was decreased significantly by CSL. 5. The amount of cytokine generation in HUVEC was decreased significantly by CSL.
Conclusions:
These results suggest that CSL supplement may attenuate oxidative stress by elevated antioxidative processes, and suppress inflammatory mediator activation. |
| Key words:
Caesalpinia sappan L., Raw 264.7 cell, HUVEC, oxidative stress, inflammation, cytokine |
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