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The Journal of Internal Korean Medicine > Volume 35(1); 2014 > Article
The Journal of Internal Korean Medicine 2014;35(1): 59-69.
온열환경과 인삼(Panax Ginseng)이 Rat의 체온, 혈액학적 변화, 면역반응에 미치는 영향
이서라1, 이인희1, 김민지1, 류재환2
1경희대학교 한의과대학 내과학교실
2경희대학교 동서의학대학원 동서의학과
Effect of Heating Condition and Panax Ginseng on Body Temperature, Hematological Changes, and Immune Response in Rat
Seo-ra Yi1, In-hee Lee1, Min-ji Kim1, Jae-hwan Lew2
1Dept. of Oriental Internal Medicine, College of Oriental Medicine, Kyung-Hee University
2East-west Medicine Department, Graduate School of East-west Medical Science, Kyung-Hee University
Correspondence  Jae-hwan Lew ,Tel: 02-958-1812, Fax: 02-958-9212, Email: intmed@khu.ac.kr
  Published online: March 30, 2014.
ABSTRACT
Objectives:
This study was designed to test the effect of heating condition and Panax ginseng on body temperature, hematologicala changes, and immune response.

Methods :
The extract from Panax ginseng was made by the pharmacy department of Kyung Hee Oriental Medical Hospital. The animals were divided into four groups; control, room temperature Panax ginseng (G), 28 ℃ heating, and 28 ℃ heating Panax ginseng (heating G). Each group has 8 Sprague-Dawley rats. We measured body weight & temperature twice a week. After 2 weeks of experiment, serum lipid level, WBC, differential count, lymphocyte proliferation and immune cytokine concentration were measured.

Results:
1. Simultaneous application of heating condition and Panax ginseng induced decreased body weight and increased body temperature. 2. Simultaneous application of heating condition and Panax ginseng induced decreased AST, ALT and BUN. 3. Simultaneous application of heating condition and Panax ginseng tended to decrease TNF-α concentration, while application of room temperature and Panax ginseng tended to increase TNF-α concentration.

Conclusions:
Simultaneous application of heating condition and Panax ginseng decreseas body weight, increases, body temperature and has a tendency to decrease TNF-α concentration.
Key words: heating, Panax ginseng, body weight, body temperature, immune, TNF-α
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