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The Journal of Internal Korean Medicine > Volume 35(2); 2014 > Article
The Journal of Internal Korean Medicine 2014;35(2): 195-207.
大黃이 고지방식이로 비만이 유발된 C57BL/6 mouse의 지방조직 염증 및 인슐린 저항성에 미치는 영향
최승범1, 마영훈1, 한양희1, 정수정2, 조홍석3
1동신한방병원 한방내과
2동신한방병원 한방부인과
3동수원한방병원 침구과
Effects of Rhei Radix et Rhizoma on Insulin Resistance and Adipose Tissue Inflammatory Response in High Fat Diet Induced Obese C57BL/6 Mice
Seung-bum Choi1, Young-hoon Ma1, Yang-hee Han1, Soo-jung Jung2, Hong-seok Cho3
1Dept. of Oriental Internal Medicine, Dong-Shin Oriental Medicine Hospital
2Dept. of Oriental Gynecology, Dong-Shin Oriental Medicine Hospital
3Dept. of Acupuncture & Moxibustion Medicine, Dongsuwon Oriental Medical Hospital
Correspondence  Yang-hee Han ,Tel: 02-2640-2931, Fax: 02-2640-2727, Email: omdhyh@hanmail.net
  Published online: June 30, 2014.
ABSTRACT
Objectives:
The purpose of this study was to investigate how Rhei Radix et Rhizoma affects on insulin resistance and adipose tissue inflammatory response in high fat diet induced obese C57BL/6 mice.

Methods :
Obesity was induced in C57BL/6 mice by high fat diet for 12 weeks. Models were divided into 3 groups (n=6) of normal diet, high fat diet (HFD), and high fat diet with Rhei Radix et Rhizoma and investigated for 12 weeks. We measured body weight, FBS and oral glucose tolerance test (OGTT), serum insulin, homeostatic model assessment-insulin resistance (HOMA-IR), weight of liver and epididymal fat pad. Inflammatory markers such as adipose tissue macrophage (ATM), tumor necrosis factor-α and interlukin-10 and CD68 of epididymal adipocyte were determined to evaluate the effect of Rhei Radix et Rhizoma on adipose tissue inflammation.

Results:
Compared with the HFD group, we observed loss of body weight and epididymal fat pad weight, improvement of glucose level and HOMA-IR, reduction of ATM and gene expression of TNF-α, CD68 in the high fat diet with Rhei Radix et Rhizoma group.

Conclusions:
This study suggests that Rhei Radix et Rhizoma has effects on insulin resistance and adipose tissue inflammatory response in high fat diet induced obese mice.
Key words: Rhei Radix et Rhizoma, insulin resistance, obesity, adipose tissue inflammation
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