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The Journal of Internal Korean Medicine 2001;22(2): 119-125. |
| 거풍지보단의 혈관이완 효능과 기전에 관한 연구 |
| 한성호, 김동은, 박동완, 정승현, 신길조, 이원철 |
| 동국대학교 한의과대학 내과학교실 |
| Studies on the Effect and Mechanism of Geupoongjibo-dan s Relaxation on a Blood Vessel |
| Sung-Ho Han, Dong-Eun Kim, Dong-Wan Park, Sung-Hyun Jeong, Gil-Cho Shin, Won-Chul Lee |
| Department of Internal Medicine, College of Oriental Medicine, Dongguk University |
| Correspondence |
Sung-Ho Han ,
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Received: June 11, 2001, Accepted: August 13, 2001, Published online: June 30, 2001. |
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| ABSTRACT |
Objectives:
This study was conducted to evaluate the effect and mechanism of Geupoongjibo-dan s relaxation of the tension of the blood vessel caused by Phenylephrine and KCl.
Methods :
In order to study the effect of Geupoongjibo-dan' s relaxation of the blood vessel tension, Geupoongjibo-dan extract was infused into Phenylephrine and KCl-induced contracted rabbit aorta strips. To analyze the mechanism of Geupoongjibo-dan s effect on the blood vessel, Geupoongjibo-dan extract infused into Phenylephrine and KCl-induced contracted strips induced by agonists after treatment of N -nitro- L-arginine, Methylene Blue.
Results:
1. Geupoongjibo-dan was very effective in relaxing the blood vessels contracted by Phenylephrine. 2. Geupoongjibo-dan was effective against Phenylephrine, than against KCI. 3. Geupoongjibo-dan s more relaxation effect on a blood vessel was terminated by N -nitro-L-arginine and methylene treatment.
Conclusion:
THis study showed that Geupoongjibo-dan s relaxation effect on a blood vessel is irrelevant to -adrenalin receptor, and it relaxes contracted vessels through cGMP channel. |
| Key words:
Geupoongjibo-dan extract, relaxation effect, blood vessel s tension. |
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