| 구기자 추출물이 납 투여에 의한 흰쥐의 신장손상에 미치는 영향 |
| 한상환1, 이호섭2, 한성희3 |
1원광대학교 한의학과 내부학교실
2원광대학교 한의학과 생리학교실
3원광보건대학 식품과학과 교실 |
| Effects of Lycii Fructus Water Extracts on the Lead-Induced Nephrotoxicity in Rats |
| Sang-Hwan Han1, Ho-Sub Lee2, Sung-Hee Han3 |
1Department of Internal medicine, College of Oriental Medicine, Wonkwang University Iksan City, Korea
2Department of physiology, College of Oriental Medicine, Wonkwang University Iksan City, Korea
3Department of Food Science Wonkwang Health Science College, Wonkwang University Iksan City, Korea |
| Correspondence |
Sang-Hwan Han ,
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Received: July 18, 2001, Accepted: August 8, 2001, Published online: June 30, 2001. |
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| ABSTRACT |
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This study was designed to investigate the effects of Korean Lycii Fructus water extract in Pb-administered rats. The Pb exposed rats were given 100 ppm and 200 ppm in the distilled water. Sixty male Sprague-Dawley rats weighing between 90 and110g were blocked into 6 groups according to body weight. The control group was fed a normal diet, without lead. The experimental groups, which was fed a normal diet plus 100 ppm and 200 ppm lead, and one group received a normal diet plus Lycii Fructus water extracts. The results: the Food intake, the weight gain, and the kidney weight content in the cadmium added groups were lower than those in the Lycii Fructus water extracts group. The contents of Pb in the kidneys of the rats were determined by using ICP(Inductively Coupled Plasma Spectrophotometer). The accumulation of lead in the kidney was lower in the Lycii Fructus water extracts group. The Plasma levels of renin activity was higher in the lead administration groups, as compared with the Lycii Fructus water extracts. Plasma levels of aldosterone activity was higher in the lead administration group, as compared with Lycii Fructus water extracts. These results suggest that Lycii Fructus water extracts has a lowering effects on the accumulation of pb on kidney and it is believed that the Lycii Fructus water extracts have some protective effects on lead-induced nephrotoxicity in rats, but the mechanism of these effects was obscure. |
| Key words:
Lycii Fructus water extracts, lead, renin activity, aldosterone activity |
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