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The Journal of Internal Korean Medicine 2003;24(2): 181-189. |
| 白鼠의 局部 腦硬塞에 대한 釣鉤藤의 神經保護 效果 |
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| The Neuroprotective Effects of Uncariae Ramulus et Uncus on focal cerebral ischemia in rats brains |
| Hyung-Su Kwon, Yong-Seong Oh, Woo-Seok Jang, So-Yeon Lee, Chi-Sang Park, Chang-Gook Park |
| Department of Circulatory Internal medicine, College of Oriental Medicine, Kyungsan University |
| Correspondence |
Woo-Seok Jang ,Tel: 053-770-2178, Fax: 053-770-2169, Email: pftft@hanmail.net
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Received: January 21, 2003, Accepted: March 10, 2003, Published online: June 30, 2003. |
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| ABSTRACT |
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The goal of this study is to investigate whether Uncariae Ramulus et Uncus can protect nerve cells against ischemic neuronal damage is caused by middle cerebral artery occlusion (MCAO) in rats brains and to investigate whether the neuroprotective effect of Uncariae Ramulus et Uncus is concerned with IEGs (immediate early genes) expression. Uncariae Ramulus et Uncus (100mg/kg) was administered immediately after 2 hours of MCAO and maintained for 7 days. On 7th days after 2 hours of MCAO, the brains of rats were sliced through the hippocampus. c-Fos immunohistochemistry stain and Cresyl violet stain were done for microscopic examination. Each number of viable neurons and c-Fos immunoreactive cells in CA1 was counted. The density of neurons and c-Fos immunoreactive cells were significantly decreased in MCAO-operated ischemic rats compared to that sham-operated rats. Administration of Uncariae Ramulus et Uncus group significantly elevated MCAOinduced decrease in density of neurons, and elevated MCAO-induced decrease in c-Fos immunoreactive cells. These results suggest that the neuroprotective effect of Uncariae Ramulus et Uncus against focal cerebral ischemia. Also, we hypothesized that neuroprotective mechanism of Uncariae Ramulus et Uncus is related to IEGs expression. |
| Key words:
Uncariae Ramulus et Uncus, cerebral ischemia, neuroprotective effect |
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