| 감초(Glycyrrhiza uralensis Fisch, GLU)가 천식모델 생쥐의 BALF 내 면역세포 및 Cytokine에 미치는 효과 |
| 한영주, 박양춘 |
| 대전대학교 한의과대학 내과학교실 |
| Effects of Glycyrrhiza uralensis Fisch on Immunocyte and Cytokine Production in Asthma Model Mouse |
| Young-Joo Han, Yang-Chun Park |
| Department of Internal Medicine College of Oriental Medicine, Daejeon University, Daejeon, Korea |
| Correspondence |
Yang-Chun Park ,Tel: 043-229-3704, Fax: 043-253-8757, Email: omdpyc@dju.ac.kr
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Received: June 12, 2004, Accepted: June 30, 2004, Published online: September 30, 2004. |
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| ABSTRACT |
Objective :
The aim is to identify the effects of Glycyrrhiza uralensis Fisch on immunocyte and cytokine production in asthmatic laboratory mice. This experiment was designed to investigate the antiallergic and antiinflamatary the effects of Glycyrrhiza uralensis Fisch on asthma.
Materials and Methods :
We measured the eosinophil, IL-4, IL-5, IL-13, IFN-γ, CD4, CD8, CD69, CCR3, CD11b, Gr-1 in bronchoalveolar lavage fluid of ovalbumin induced asthmatic mice.
Results:
Glycyrrhiza uralensis Fisch increased the proliferation of eosinophils, IL-4, IL-5, IL-13, IgE, granulocyte, CCR3, CD4, IgE, CD69. Glycyrrhiza uralensis Fisch increased the proliferation of IFN-γ.
Conclusion:
Results suggest that Glycyrrhiza uralensis Fisch extract is useful in treatment and prevention allergic asthma. |
| Key words:
Glycyrrhiza uralensis Fisch, cytokine, antiallergy |
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