|
|
The Journal of Internal Korean Medicine 2004;25(3): 427-439. |
| 保肺養營煎이 흰쥐의 氣管支平滑筋張力과 면역에 미치는 影響 |
| 이강녕, 김희철 |
| 동신대학교 한의과대학 간계내과학 교실 |
| Effects of Bopheyangyoungjeon(BYJ) on airway smooth muscle, airway inflammation, IgE and Interleukin-4 in mouse model of allergic bronchial asthma |
| Kang-Nyoung Lee, Hee-Chul Kim |
| Department of Hepatic Internal Medicine, College of Oriental Medicine, Dongshin University |
|
|
|
Received: July 5, 2004, Accepted: August 2, 2004, Published online: September 30, 2004. |
|
|
|
| ABSTRACT |
|
It has been reported that Bopheyangyoungjeon(BYJ) has an effect on deficiency allergic asthma(虛喘) clinically. The aim of this study was to determine an appropriate dosage of BYJ to treat asthma. In order to study the effects of orally administered BYJ on allergic asthma, mice were pretreated with three oral doses of the herbal solution of BYJ before antigen sensitization. 2 days later Mice were actively sensitized with a subcutaneous injection of ovalbumin and 13 days later ovalbumin aerosols were used to provoke asthmatic reaction. Serum level of IgE, IL-4, WBC, RBC, HGB, cell numbers in bronchoalveolar lavage fluid(BALF), and in vitro isometric contractile responses of the isolated tracheal smooth muscle(TSM) to acetylcholine(ACh, 0.1-1000μM), KCl were measured. The results were as follows ; 1. Contractile responses of TSM to ACh significantly increased in C group at Ach 0.3, 1, 3, 10, 30, 100, 300, 1000μ M(P<0.05, P<0.01) and increased in D at 0.1, 0.3, 3, 30, 100, 300, 1000μM. 2. The sensitivity of TSM to Ach increased more in A, B group, but it was not significant. 3. The maximal contractile response of TSM to ACh decreased more significantly in C group(P<0.01) and D group(P<0.05) than in the control group. 4. The maximal contractile response of TSM to KCl decreased more significantly in B group and C group(P<0.001) than in the control group. 5. The counts of lymphocytes in BALF decreased more significantly in B group and D group(P<0.05) than in the control group. 6. The counts of macrophages in BALF decreased more significantly in B group, C(P<0.05) than in the control group. 7. Interleukin-4 in BALF decreased more significantly in A group and C group(P<0.05) than in the control group. 8. Serum IgE level increased more significantly in B group and C group(P<0.05) than the control group. 9. The counts of WBC, RBC, HGB in blood increased more significantly in A group than the control group. The above results support a role for BYJ orally administered in treatment of deficiency allergic Asthma. |
| Key words:
Bopheyangyoungjeon, IgE, Interleukin-4, Bronchial asthma |
|
|
|
PDF Links
Full text via DOI 
Download Citation 
