| 茵蔯淸肝湯이 인체 간암세포의 혈관생성인자 발현에 미치는 영향 |
| 김철우, 김영철, 이장훈, 우홍정 |
| 경희대학교 한의과대학 간계내과학교실 |
| The Effects of Injinchunggan-tang(Yinchenqinggan-tang) on Expression of Angiogenic Factors in HepG2 Cells |
| Chul-woo Kim, Young-chul Kim, Jang-hoon Lee, Hong-jung Woo |
| Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University |
| Correspondence |
Hong-jung Woo ,Tel: 02-958-9118, Fax: 02-958-9120, Email: hjwoo@khu.ac.kr
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Received: February 10, 2006, Accepted: February 27, 2006, Published online: March 30, 2006. |
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| ABSTRACT |
Objectives:
This study was designed to investigate the effects of Injinchunggan-tang(Yinchenqinggan-tang) on expression of angiogenic factors in HepG2 cells.
Materials and Methods :
The mRNA expression levels and protein secretion levels of angiogenic factors were measured using quantitative RT-PCR, Western blot and ELISA assay respectively in Injinchunggan-tang-treated and untreated HepG2 cells.
Results:
Injinchunggan-tang(Yinchenqinggan-tang) reduced mRNA expression levels and protein secretion levels of angiogenic factors, especially VEGF, bFGF and TGF-β1 in HepG2 cells.
Conclusion:
Results indicate that Injinchunggan-tang (Yinchenqinggan-tang) inhibits expression of angiogenic factors in HepG2 cells. Further, results suggest that Injinchunggan-tang (Yinchenqinggan-tang) inhibits angiogenic effects in HCC. |
| Key words:
Injinchunggan-tang(Yinchenqinggan-tang), HepG2 cell, angiogenic factor, VEGF, bFGF, TGF-β1 |
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