| 眞武湯이 백서의 갑상선기능저하증에 미치는 영향 |
| 최인구, 채은영, 장선규, 조충식, 김철중 |
| 대전대학교 한의과대학 신계내과학교실 |
| Effects of Jinmutang (JMT) on Hypothyroidism in Rats |
| In-goo Choi, Eun-young Chae, Sun-kyu Chang, Chung-sik Cho, Cheol-jung Kim |
| Department of Internal Medicine, College of Oriental Medicine, Daejeon University, Daejon, Korea. |
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Published online: December 30, 2006. |
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| ABSTRACT |
Objectives:
This study was done to investigate the effects of JMT on hypothyroidism in rats.
Materials and Methods :
After pretreatment with 50㎎/㎏ thiouracil for 30 days, the experimental group was treated with 0.56g/㎏ JMT orally and the control group was treated with 0.56g/㎏ of normal saline instead for 20 days. The various indicators related to hypothyroidism were measured, such as T3-uptake content, T3 content, T4 content, TSH content, hematological values, enzyme activity, total cholesterol content, Na+ content change in the serum and body weight of rats induced by thiouracil.
Results:
The JMT-treated group showed significant increase in comparison with the control group in serum T3-uptake and T4 content. The JMT-treated group also showed significant decrease in comparison with the control group in serum TSH content. However, the JMT-treated group did not show significant increase in comparison with the control group in serum T3 content. The JMT-treated group showed significant increase in comparison with the control group in serum RBC. The JMT-treated group showed significant decrease in comparison with the control group in serum CPK, ALP, LDH content and serum total cholesterol content. The JMT-treated group did not show significant increase in comparison with the control group in serum Na+ content. The JMT-treated group showed significant decrease in comparison with the control group in body weight.
Conclusions:
These results suggest that JMT is useful in treatment of hypothyroidism. |
| Key words:
Jinmutang(JMT), Hypothyroidism |
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