| 加味保我湯 및 數種 한방처방의 항암효과에 대한 연구 |
| 성현제 |
| 한라한방병원 |
| Anti-cancer Effects of Kamiboa-tang and some other Traditional Medical Prescriptions |
| Hyun-jea Sung |
| Halla Oriental Hospital |
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Published online: June 30, 2007. |
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| ABSTRACT |
Objectives:
Anticancer and immune-modulating effects of several Korean medical prescriptions including Yukgunja-tang, Bohwa-tang, Sogam-won, and Kamiboa-tang were investigated.
Methods :
In vitro anti-cancer effects were measured by cytotoxicity MTT assay using SNU-1 gastric cancer cell lines. In vivo anti-cancer effects were measured by increased life span of S-180 sarcoma-injected ICR mouse. Immune-modulating effects were analyzed by measuring hemagglutinin titer, appearance of rosette forming cells, lymphocyte proliferation, and phagocytic index in methotrexate-pretreated mice.
Results:
In vitro assay showed that only Sogam-won showed cytotoxic effect with IC50 of 87.9 ㎍/㎖. All other prescriptions showed no cytotoxic effects against SNU-1 gastric cancer cell line. However, in vivo assay showed that Sogam-won showed lowest anti-cancer effects in contrast to its highest cytotoxic effects. Kamiboa-tang, which showed no cytotoxic effect, showed the highest in vivo anticancer effects, with increased life span of 140%. Kamiboa-tang showed significant immune-enhancing activities by significantly increasing rosette forming cells, lymphocyte proliferation, and phagocytic index in methotrexate-pretreated mice (P<0.05).
Conclusion:
The anticancer effect of Kamiboa-tang is not mediated by direct inhibition of cancer cells but is mediated by improving immune reactions against cancer cells. |
| Key words:
Anti-cancer, Cytotoxicity, Immune function, Korean Medical Prescription, Kamiboa-tang |
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