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The Journal of Internal Korean Medicine 2007;28(3): 608-614. |
| 知母 추출물이 MCF-7 세포의 생존율에 미치는 영향 |
| 김형우1, 조수진2, 김부여1, 조수인1 |
1동신대학교 한의과대학
2고려대학교 의과대학 |
| Anti-oxidant Effects of Anemarrhenae Rhizoma in Three Different Lineages |
| Hyung-woo Kim1, Su-jin Cho2, Bu-yeo Kim1, Su-in Cho1 |
1College of Oriental medicine, Dongshin University
2College of medicine, Korea University |
| Correspondence |
Su-in Cho ,Tel: 061-330-3513, Fax: 061-330-3519, Email: sicho@dsu.ac.kr
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Published online: September 30, 2007. |
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| ABSTRACT |
Objectives:
This study was carried out to investigate anti-proliferative effects on MCF-7 human breast cancer cells of Anemarrhenae Rhizoma (AR) extract. Breast cancer is the most common disease in Korean women. Despite remarkable improvements in treatment strategies against various cancers during the past 40 years, breast cancer still remains as one of the main causes of cancer mortality among women the whole world over.
Methods :
Se investigated the effects of AR on cytotoxicity of MCF-7 human breast cancer cells in various extract conditions (n-hexane, ethyl acetate, butanol and water fraction).
Results:
The extract of Anemarrhenae Rhizoma inhibits the proliferation of MCF-7 cells in a dose dependent manner. Especially, the ethyl acetate fraction of Anemarrhenae Rhizoma showed specific cytotoxicity on MCF-7 cells.
Conclusions:
In conclusion, it can be concluded that Anemarrhenae Rhizoma extract has an anti-proliferative effect on MCF-7 human breast cancer cells. Especially, the ethyl acetate fraction is most effective to inhibit proliferation of MCF-7 cells. |
| Key words:
Anemarrhenae Rhizoma, MCF-7, anti-cancer drug, breast cancer |
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