The Histopathology of <i>Hyeungbangjihwang-tang</i> Extracts on the Liver Cirrhosis of Fisher 344 Rats Induced by Long Time Carbon Tetrachloride Injection.

Kim, Seong-mo

The Journal of Internal Korean Medicine > Volume 29(2); 2008 > Article

Original Article

The Journal of Internal Korean Medicine 2008;29(2): 375-384.

사염화탄소의 長期投與로 유발된 白鼠肝硬變에 대한 荊防地黃湯의 조직병리학적 영향

김승모

대구한의대학교 한의과대학 간계내과학교실

The Histopathology of Hyeungbangjihwang-tang Extracts on the Liver Cirrhosis of Fisher 344 Rats Induced by Long Time Carbon Tetrachloride Injection.

Seong-mo Kim

Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University

Correspondence

Seong-mo Kim ,Tel: 053-651-2600, Email: heuwon@hanmail.net

Published online: June 30, 2008.

ABSTRACT

Objective :
This study was carried out to investigate the effects of oral administration of Hyeungbangjihwang-tang (HBJHT) on the liver cirrhosis of rats induced by Carbon tetrachloride for 10 weeks.

Method:
The histopathological changes were observed. The HBJHT extracts were daily dosed at 50, 100 and 200㎎/㎏ for 12 weeks.

Results:
Severe hepatocellular necrosis and ballooning, hyperplasia of connective tissue, subdued reduction of hepatic lobule, and hyperplasia of bile duct in portal triad were dramatically decreased in the HBJHT-treated group compared to that of the Carbon tetrachloride-treated control group in histopathological observation. The diameter of hepatic lobules was significantly enlarged in the HBJHT-treated group compared to that of the Carbon tetrachloride-treated control group, and the amounts of connective tissue, degenerative cells and bile ducts were significantly and dose-dependently decreased.

Conclusion:
It is concluded that HBJHT has a significant recovering effect on the liver of rats induced by carbon tetrachloride.

Key words: Hyeungbangjihwang-tang(HBJHT), liver cirrhosis, Carbon tetrachloride