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The Journal of Internal Korean Medicine 2008;29(2): 490-499. |
| 천화분 추출물이 혈관신생 및 암세포성장에 미치는 영향 |
| 김동우, 이종훈, 유화승, 조정효, 이연월, 손창규, 조종관 |
| 대전대학교 동서암센터 |
| Effects of Trichosanthes kirilowii Extract against Angiogenesis
and Various Tumor Cells' Growth |
| Dong-woo Kim, Jong-hoon Lee, Hwa-seung Yoo, Jung-hyo Cho, Yeon-weol Lee, Chang-gue Son, Chong-kwan Cho |
| Department of East-West Cancer Center, Oriental Hospital of Daejeon University |
| Correspondence |
Chong-kwan Cho ,Tel: 82-42-470-9132, Fax: 82-42-470-9006, Email: altyhs@dju.ac.kr
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Published online: June 30, 2008. |
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| ABSTRACT |
Objectives:
This study was aimed to elucidate the effects of Trichosanthes kirilowii extract (TKE) on the angiogenesis
and growth of tumor cells.
Methods :
Tube formation assay was performed by using human umbilical vein endothelial cells (HUVEC), and
anchorage dependent colony assay was performed by using B16-F10 melanoma, Hep G2 and HT1080, CT-26 and SNU-1 cells.
Results:
For HUVEC, TKE at a level of more than 100 ㎍/㎖ suppresses cell growth. For HUVEC at 100 ㎍/㎖ and
greater TKE density, the formation of tubes was suppressed in a dose-dependant manner. TKE controls the colony formations
of B16-F10 melanoma cells, CT 26 cells, and Hep G2 cells, and its effect is proportional to density. In HT1080 cells and
SNU-1 cells, formation is suppressed regardless of density.
Conclusions:
From these results, it could be concluded that TKE has significant properties on anti-angiogenesis and
growth inhibiting of tumor cells. It is suggested that TKE will be a good candidate for new drugs or therapeutics for
anti-angiogenesis. |
| Key words:
Trichosanthes kirilowii Extract(TKE), Anti-angiogenesis, Cancer |
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