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The Journal of Internal Korean Medicine 2008;29(3): 629-640. |
| 竹瀝이 흰쥐의 中大腦動脈 및 全腦虛血 폐쇄 허혈모델에 미치는 영향 |
| 김재홍, 홍진우, 나병조, 박성욱, 정우상, 문상관, 박정미, 고창남, 조기호, 김영석, 배형섭 |
| 경희대학교 한의과대학 2내과학교실 |
| Effect of Bambusae Caulis in Liquamen(Jukryuk) on Ischemic Damage to 4 Vessel Occlusion and Middle Cerebral Artery Occlusion in Mice |
| Jae-hong Kim, Jin-woo Hong, Byung-jo Na, Seong-uk Park, Woo-sang Jung, Sang-kwan Moon, Jung-mi Park, Cham-nam Ko, Ki-ho Cho, Young-suk Kim, Hyung-sup Bae |
| Department of Cardiovascular ＆ Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung Hee University |
| Correspondence |
Byung-jo Na ,Tel: 02-3457-9006, Fax: 02-3457-9100, Email: hani114@paran.com
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Published online: September 30, 2008. |
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| ABSTRACT |
Objective :
The purpose of this study was to investigate the neuroprotective effect of Jukryuk on 4-vessel occlusion(4-VO) and middle cerebral artery (MCA) ischemia.
Method:
After administration of Jukryuk, we compared the Jukryuk-treated group, the control, and the sham groups, in view of several points as follows 1) We evaluated the damage characterized by coagulative cell change of pyramidal neurons and pronounced gliosis in each group 2) We counted the number of normal pyramidal shapes after ischemia in each group 3) Immunohistochemistry (cyclooxygenase-2) 4) In focal ischemic injury model, we measured the volume of ischemic area
Results:
In this experiment, the effect of Jukryuk was determined to be protecting neuron cell shape, reducing the number of neuron cells damaged by ischemia and the volume of the ischemic area. In immunohistochemistry, Jukryuk reduced cyclooxygenase-2 expression
Conclusions:
According to this study, Jukryuk can protect neuron cells from injury by cerebrovascular ischemia |
| Key words:
Bambusae Caulis in Liquamen(Jukryk), neuroprotective effect, 4-vessel occlusion(4-VO), middle cerebral artery(MCA) ischemia. |
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