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The Journal of Internal Korean Medicine 2008;29(3): 684-702. |
| 知柏地黃丸加味가 monocrotaline으로 유발된 흰쥐의 고혈압 병태모델에 미치는 영향 |
| 김종원, 안정조, 조현경, 유호룡, 설인찬, 김윤식 |
| 대전대학교 한의과대학 심계내과학교실 |
| The Effects of Jibeakjihwanghwangami (JJHG) on Monocrotaline-induced Hypertensive
Rats |
| Jong-won Kim, Joung-jo An, Hyun-kyung Jo, Ho-ryong Yoo, In-chan Seol, Yoon-sik Kim |
| Department of Internal Medicine, College of Oriental Medicine, Daejeon University |
| Correspondence |
Yoon-sik Kim ,Tel: 042-229-6806, Fax: 042-254-3403, Email: yoonsik@dju.ac.kr
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Published online: September 30, 2008. |
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| ABSTRACT |
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This experiment was performed to determine the effect of Jibeakjihwanghwangami(JJHG) on hypertension in
monocrotaline-induced hypertensive rats. The results obtained were as follows :
1. JJHG showed a safety in cytotoxicity and toxicity of liver.
2. JJHG showed scavenging activity on DPPH free radicals and SOD-like activity.
3. JJHG showed an inhibitory effect on ACE.
4. JJHG significantly decreased blood pressure and pulse in monocrotaline-induced hypertensive rats.
5. JJHG significantly decreased the levels of plasma aldosterone in monocrotaline-induced hypertensive rats.
6. JJHG significantly decreased the levels of potassium in monocrotaline-induced hypertensive rats.
7. JJHG significantly decreased the levels of uric acid, BUN, and creatinine in monocrotaline-induced hypertensive rats.
These results suggest that JJHG might be effective in treatment and prevention of hypertension. |
| Key words:
Jibeakjihwanghwangami(JJHG), hypertension, monocrotaline-induced hypertensive rats |
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