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The Journal of Internal Korean Medicine > Volume 33(2); 2012 > Article
Original Article
The Journal of Internal Korean Medicine 2012;33(2): 231-242.
재발성 아프타성 구내염 환자에 대한 가미육미지황탕의 효능
김주연, 김진성, 손지희, 선종기, 강경, 장승원, 손지영, 류봉하
경희대학교 한의과대학 비계내과학교실
Efficacy of Gamiyukmijihwang-tang on Recurrent Aphthous Stomatitis
Ju-yeon Kim, Jin-sung Kim, Ji-hee Son, Jong-ki Seon, Kyung Kang, Seung-won Jang, Ji-young Son, Bong-ha Ryu
Dept. of Gastroenterology, College of Oriental Medicine, Kyung-Hee University
Correspondence  Jin-sung Kim ,Tel: 02-958-8895, Email: oridoc@khu.ac.kr
  Published online: June 30, 2012.
ABSTRACT
Objectives:
This study was designed to investigate the Efficacy of Gamiyukmijihwang-tang on Recurrent Aphthous Stomatitis.

Methods :
We surveyed 10 recurrent aphthous stomatitis patients visited the oral diseases clinic in the Kyung Hee University Oriental Medicine Hospital from September, 2011 to March, 2012. Before and 2 weeks after taking Gamiyukmijihwang-tang, the subjects were evaluated on clinical characteristics of recurrent aphthous stomatitis, severity of pain using visual analogue scale (VAS), quality of life about oral health (based on the 14-item Oral Health Impact Profile-14) and yin-deficiency condition (based on the 10-item Yin-deficiency Questionnaire). Then, 5 patients who had already finished treatment were assessed about recurrence of recurrent aphthous stomatitis by telephone survey 6 weeks later.

Results:
After 2 weeks taking Gamiyukmijihwang-tang, clinical characteristics of 10 patients of recurrent aphthous stomatitis improved; their severity of pain, quality of life about oral health and yin-deficiency condition improved significantly. After 6 weeks, 3 of 5 patients who had already finished treatment didn't experience recurrence of recurrent aphthous stomatitis. The other 2 patients experienced a recurrence, but their clinical characteristics of recurrent aphthous stomatitis improved significantly.

Conclusions:
Gamiyukmijihwang-tang is effective on recurrent aphthous stomatitis. Studies with a larger number of cases and longer follow-up will be needed in the future.
Key words: recurrent aphthous stomatitis, Yukmijihwang-tang (Liuweidihuang-tang)
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