| 調胃升淸湯 추출액이 비만유도 쥐의 지질대사, 항산화계 및 염증반응계에 미치는 영향 |
| 오성원, 김병우 |
| 상지대학교 부속한방병원 내과학교실 |
| Effects of Jowiseungcheung-tang Extract on the Lipid Metabolism, Anti-oxidation and
Inflammatory Reflex High Fat Diet Obese Rats |
| Sung-won Oh, Byoung-woo Kim |
| Dept. of Internal Medicine, Oriental Medical college, Sang-Ji University |
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Published online: March 30, 2013. |
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| ABSTRACT |
Objectives:
The purpose of this study was to investigate the effects of Jowiseungcheung-tang (JWSCT) extract on the lipid metabolism, anti-oxidation and inflammatory reflex.
Methods :
Male Sprague-Dawley rats were fed a high fat diet for 8 weeks and were randomly divided into 4 groups (10 mice in each group): control group, 100 mg/kg JWSCT group, 200 mg/kg JWSCT group, 300 mg/kg JWSCT group. The control group was administered 100 mg/kg of water, but the other three groups were administered 100, 200, 300 mg/kg JWSCT extract for 4 weeks. After 4 weeks, we measured lipid level, thiobarbituric acid reactive substance (TBARS), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and cytokines in plasma and liver. The gene expression level and the ratio of apo-B and apo-E were then investigated by way of reverse transcription -polymerase chain reaction (RT-PCR).
Results:
In the JWSCT group, compared with the control, free fatty acid, triglyceride, total cholesterol, LDL-cholesterol, TBARS, IL-1β, IL-6 and TNF-α decreased significantly in plasma and liver. However HDL-cholesterol, IL-10, GSH-Px, SOD and CAT increased. In the JWSCT group, compared with the control, the gene expression level and the ratio of apo-A and apo-E decreased significantly in the RT-PCR analysis.
Conclusions:
The extract of JWSCT has anti-obesity, anti-inflammatory and anti-oxidant effects. |
| Key words:
Jowiseungcheung-tang , lipid metabolism, anti-oxidation, inflammatory, anti-obesity |
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