Development Cut-off Value for <i>Yin-deficiency</i> Questionnaire and Diagnostic Ability of
<i>Yin-deficiency</i> in Xerostomia

Jang, Seung-won; Kim, Jin-sung

The Journal of Internal Korean Medicine > Volume 35(4); 2014 > Article

Original Article

The Journal of Internal Korean Medicine 2014;35(4): 483-497.

구강건조증 환자에서 음허 측정 설문지 절단점 개발 및 진단능 평가

장승원, 김진성

경희대학교 한의과대학 비계내과학교실

Development Cut-off Value for Yin-deficiency Questionnaire and Diagnostic Ability of Yin-deficiency in Xerostomia

Seung-won Jang, Jin-sung Kim

Dept. of Gastroenterology, College of Korean Medicine, Kyung-Hee University

Correspondence

Jin-sung Kim ,Tel: 02-958-8895, Email: oridoc@khu.ac.kr

Published online: December 30, 2014.

ABSTRACT

Objectives:
The aims of study were developing cut-off value of Yin-deficiency questionnaire (YDQ) for diagnosis of Yin-deficiency (YD) and compare diagnostic ability between YDQ and Yin-deficiency scale score (YDS) in xerostomia patients.

Methods:
We recruited 58 xerostomia patients. They were diagnosed YD or non-YD by 3 Korean medicine doctors (KMD). We assessed YD using YDQ and YDS. We evaluated xerostomia using VAS, Dry Mouth Symptom Questionnaire (DMSQ), Salivary Flow Rate (SFR), oral moisture on buccal mucosa and tongue surface (OMB and OMT). We surveyed tongue coatings using Winkel Tongue Coating Index (WTCI).

Results:
We diagnosed 23 patients YD and 35 patients non-YD. There were no significant differences of age, sex and body mass index between the YD and non-YD groups. Using receiver operating characteristic curve analysis, the optimal cut-off value of YDQ was defined as 304. Sensitivity, specificity and Youden index of YDQ were 86.96%, 71.43% and 1.5839 respectively. Using Cohen’s coefficient of agreement, we found that degree of agreement between KMD and YDQ diagnosis was moderate (κ=0.524, p<0.001). Using Pearson’s correlation analysis, we found concurrent validity of YDQ and YDS were significant correlated. Using area under curve value, we found diagnostic ability between YDQ and YDS were not significantly different (p=0.505), but there were more strong correlations between DMSQ-symptoms and YDQ (r=0.731, p<0.001) than correlations between DMSQ-symptoms and YDS (r=0.418, p<0.01).

Conclusions:
The cut-off value of YDQ can diagnose YD in xerostomia and diagnostic ability of YDQ in xerostomia is better than YDS.

Key words: Xerostomia, Yin-deficiency, Yin-deficiency questionnaire, cut-off value