| 羌活愈風湯이 腦虛血로 유도된 大腦神經細胞損傷에 미치는 영향 |
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| Effects of Kangwhalyupung-tang on the Cerebral Neuronal Damage induced by Ischemia |
| Seoung-geun Lee2, Beong-sun Mun1, Chung-yeon Hwang1, Keong-yo Kim1, Geon-mok Lee1, Kang-keong Sung1, Dae-yong Lee2 |
1Department of Internal Medicine, College of Oriental Medicine, Wonkwang University
2Department of Internal Medicine, College of Oriental Medicine, Wonkwang University, Kunpo Hospital |
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Received: September 23, 2002, Accepted: October 23, 2002, Published online: March 30, 2003. |
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| ABSTRACT |
Objective :
Experimental studies have been done to elucidate the effect of kangwhalyupung-tang(KWYPT) on neuronal cell damage induced by brain ischemia.
Method:
The cytotoxic effect of ischemia was measured in the MTS assay cultures. MTS assay, INT assay, neurofilament(NF) enzymeimmuno assay(EIA). And the KWYPT on ischemia-induced neurotoxicity were examined by in vitro assays.
Results:
1. The KWYPT protected effectively neuronal cell-death resulted from brain ischemia induced by the treatment of 95%N2/5%CO2 for 10 min in those dependent fashion. 2. The KWYPT effectively increased the amount of NF resulting from brain ischemia , induced by the treatment of 95%N2/5%CO2 for 15 min in those dependent fashions.
Conclusions:
KWYPT protects the brain ischemia-induced neurotoxicity through the increase of cell viability and of neurofilament in dose-dependent manner. |
| Key words:
Kangwhalyupung-tang, Cerebral Neuronal Damage |
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