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The Journal of Internal Korean Medicine 2003;24(1): 44-54. |
| 흰쥐의 肝損傷에 대한 加減茵芍桃花湯의 肝보호효과 |
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| Protective effects of Gagaminjakdowha-Tang on liver injury of rats |
| Tae-houn Lee, Jae Chun Kang, Byong woo Kim |
| Department of Oriental Medicine, College of Oriental Medicine. Sangji University |
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Received: October 11, 2002, Accepted: December 21, 2002, Published online: March 30, 2003. |
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| ABSTRACT |
Objectives:
This study was done to investigate the protective effects of Gagaminjakdowha-Tang on liver injury of rats induced by CCl4 and d-galactosamine.
Methods :
All animals were divided into 5 groups, those were normal group(untreated), control group(treated with 0.9% Saline solution), sample I group(200 mg/kg administrated), sample II group(400 mg/kg administrated), Silymarin(200 mg/kg administrated) group. Liver injury of rats were induced by CCl4 and d-galactosamine, and then the serumtransaminase(ALT & AST) alkaline phosphatase(ALP), lactic dehydrogenase(LDH) for enzyme activities, Liver cytosol malondialdehyde(MDA), catalase, superoxide dismutase(SOD), glutathione S-transferase(GST) and glutathione-peroxidase(GPX) for enzyme activities were measured.
Results:
The inhibitory effects on the serum ALT activities were noted in both sample I and sample II group. The inhibitory effects on the serum AST activities were noted in only sample II group. The inhibitory effects on the serum ALP activities were noted in both sample I and sample II group. The inhibitory effects on the serum LDH activities were noted in only sample II group. The inhibitory effects on the liver cytosol malondialdehyde were noted in only sample II group. The decresed effects on the liver cytosol catalase activities were inhibited in only sample II group. The decresed effects on the liver cytosol superoxide dismutase activities were inhibited in only sample II group. The decresed effects on the liver cytosol GST activities were inhibited in only sample II group. The decresed effects on the liver cytosol GPX activities were inhibited in only sample II group. The inhibitory effects of the serum ALT activities were noted in both sample I and sample II . The inhibitory effects of the serum AST activities were noted in only sample II group. The inhibitory effects of the serum ALP activities were noted in only sample II group. The inhibitory effects of the serum LDH activities were noted in both sample I and sample II group.
Conclusions:
Gagaminjakdowha-Tang has protective effects against liver injury in rats induced by CCl4 and dgalactosamine. |
| Key words:
Gagaminjakdowha-Tang, liver injury, d-galactosamine, CCl4, Silymarin |
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