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The Journal of Internal Korean Medicine 2003;24(3): 561-568. |
| 뇌경색 환자의 말초혈액 단핵구에서 저당탐의 Cytokines 조절효과 |
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| The regulatory effect of cytokines production from Peripheral blood mononuclear cells in cerebral infarction patients of Jeodang-tang |
| Sei Young Kang, Byung Soon Moon, Kwang Ro Lee, Sang Su Cheong, So Young Lee, Hyun Hee Ryu, Kuk Jin Sim, Sang Kwan Lee, Kang Keyng Sung |
| Department of Neuroscience and Internal Medicine, College of Oriental Medicine, Wonkwang University |
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Published online: September 30, 2003. |
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| ABSTRACT |
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The herbal formulation Jeodang-tang (JDT) has long been used for various cerebrovascular diseases. But scientific investigation has been carried out very little. The aim of the present study is to investigate the effect of JDT on the production of various cytokines in cerebral infarction (CI) patients. Peripheral blood mononuclear cells (PBMC) obtained from the patient with CI were cultured for 24hs in the presence or absence of lipopolysaccharide (LPS) or phytohaemagglutinin (PHA). The amount of interleukin (IL)-4, IL-10 and transforming growth factor (TGF)-1, in culture supernatant, was significantly increased in the LPS or PHA treated cells compared to unstimulated cells (P<0.05). I also show that increased cytokines IL-4, and IL-10 level was significantly inhibited by JDT in a dose-dependent manner. Maximal inhibition rate of IL-4 and IL-10 production by JDT was 45 2% and 51 5% for LPS-stimulated cell and 41.5 3% and 70.8 2% for PHA-stimulated cells, respectively (P<0.05). On the other hand, JDT significantly increased the LPS or PHA-induced TGF-1 production (P<0.05). These data suggest that JDT has a regulatory effect on the cytokines production, which might explain its beneficial effect in the treatment of CI patients. |
| Key words:
Jeo Dang-Tang; Lipopolysaccharide; Phytohaemagglutinin; Cerebral infarction; Cytokines |
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