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The Journal of Internal Korean Medicine 2004;25(2): 159-166. |
| 補中益氣湯加味方에 의한 肥滿細胞媒介性卽刻型알레르기 反應의 抑制 |
| 최정온1, 김진만1, 이승언1, 신조영1, 이시형2 |
1원광대학교 한의과대학 폐계내과학교실
2원광대학교 한의학 전문대학원 |
| Inhibition of mast cell-mediated immediate-type allergic reactions by Bojungikgitanggamibang |
| Jeong-On Choi1, Jin-man Kim1, Seung-Eon Lee1, Jo-Young Shin1, Si-Hyeong Lee2 |
1Department of Internal Medicine, College of Oriental Medicine, Wonkwang University
2Professional Graduate School of Oriental Medicine, Wonkwang Universit |
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Received: March 17, 2004, Accepted: March 29, 2004, Published online: June 30, 2004. |
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| ABSTRACT |
Objective :
Mast cells are a potent source of mediators that regulate inflammatory response in allergies and asthma. The author studied the effect of Bojungikgitanggamibang(BITB) on mast cell-mediated anaphylactic reaction.
Method:
When BITB was given as pre-treatment at concentrations ranging from 0.01 to 1 mg/ml, the histamine release from rat peritoneal mast cells induced by compound 48/80 was reduced in a dose-dependent manner.
Result:
BITB dose-dependently inhibited compound 48/80-induced systemic anaphylactic shock. BITB also inhibited passive cutaneous anaphylaxis activated by anti-dinitrophenyl IgE. In addition, BITB inhibited phorbol 12-myristate 13- acetate and A23187-induced interleukin-6 secretion from human mast cell line HMC-1 cells.
Conclusion:
These results indicate that BITB may be actively anti-allergic. |
| Key words:
Bojungikgitanggamibang, anti-allergic activity, systemic anaphylactic shock |
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