| 대황이 뇌허혈 유발 노령 흰쥐의 해마 c-fos 및 c-jun 발현에 미치는 영향 |
| 백진원, 김주원, 정승현, 신길조, 이원철 |
| 동국대학교 한의과대학 내과학교실 |
| Effects of Rhei Rhizoma on c-fos and c-jun Expressions in the Hippocampus of Old BCAO Rats |
| Jin-Won Paik, Ju-Won Kim, Sung-Hyun Jeong, Gil-Cho Shin, Won-Chul Lee |
| Department of Internal Medicine, College of Oriental Medicine, Dongguk University |
| Correspondence |
Jin-Won Paik ,Tel: 031-710-3734, 3753, Fax: 031-710-3780, Email: tetris37@hanmail.net
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Received: July 12, 2004, Accepted: July 28, 2004, Published online: September 30, 2004. |
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| ABSTRACT |
Objective :
In this study old BCAO rats were observed for effects of ‘Dea-Hwang’ on brain ischema injury, because risk of stroke increases with age.
Method:
The brain ischema injury was induced by temporarily closing carotids on both sides in a low blood pressuer state and Dea-Hwang was administered orally to 18 month-old BCAO rats.
Results and Conclusions :
The ischemically damaged Hippocampus and c-fos and c-jun expression were analyzed by immunohistochemical staining and results are summarized as follows: 1. The c-fos expression after inducing a brain ischema injury in the hippocampus was more inhibited in the dosed group than in the control group. 2. The normalized optical density of c-fos expression was more reduced in the CA1, CA2, and DG areas of the dosed group than in those of the control group. 3. The c-jun expression after inducing brain ischema injury in the hippocampus was more inhibited in the dosed group than in the control group. 4. The normalized optical density of c-jun expression was more reduced in the CA1 area of the dosed group than in that of the control group. |
| Key words:
Dae-hwang, c-fos, c-jun, the aged BCAO rats, hypoxia |
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