| 解熱湯의 抗炎症, 抗酸化, 抗老化 作用에 대한 實驗的 硏究 |
| 곡정강1, 김진주2, 노영래1, 이성헌1, 정승연1, 정희재1, 정승기1 |
1경희대학교 한의과대학 폐계내과학 교실
2경희대학교 약학대학 약리학교실 |
| Experimental Research on the Effect of Haeyeol-tang |
| Cheng-kang Chu1, Jin-ju Kim2, Young-lae Roh1, Sung-hun Lee1, Seung-yeon Jeong1, Hee-jae Jung1, Sung-ki Jung1 |
1Dept. of Internal Medicine College of Oriental Medicine, Kyung Hee University
2Dept. of Pharmacology, College of Pharmacy, Kyung Hee University |
| Correspondence |
Sung-ki Jung ,Tel: 02-958-9147, Fax: 02-958-9148, Email: jskes@unitel.co.kr
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Published online: December 30, 2007. |
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| ABSTRACT |
Objectives:
The purpose of this study wss to examine the effect of Haeyeol-tang on infectious disease of respiratory system.
Methods :
Haeyeol-tang was used by cold storage after dilution with 1, 10 and 100μg/ml of PBS, from dried material as extracted material with extraction with 50% ethanol. Statistical significance was examined through measuring TNF-α, RT-PCR, DPPH, nitric oxide(NO), and MTT of Raw264.7 cells activated with LPS.
Results:
For the toxicity experiment of Haeyeol-tang, almost no toxicity was shown on cells in the concentration ranges of 1, 10 and 100μg/ml. For the effect of NO production, Haeyeol-tang showed significant (p<0.001) decrease of NO production, according to its concentration. For the effect on the eliminating activity of DPPH radical, Haeyeol-tang showed increasing tendency of eliminating activity of DPPH radical, according to its concentration. For the effect on revelation of NOS2 enzyme, Haeyeol-tang showed inhibiting tendency against the revelation of NOS2, according to its concentration. For the effect on the TNF-α production, Haeyeol-tang showed significant (p<0.001) decrease of TNF-α production.
Conclusions:
This result means that Haeyeol-tang is effective for anti-inflammation, as well as excellent effect for anti-oxidation and anti-aging. |
| Key words:
Heayeol-tang, MTT, DPPH, TNF-α |
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