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The Journal of Internal Korean Medicine > Volume 29(2); 2008 > Article
Original Article
The Journal of Internal Korean Medicine 2008;29(2): 348-358.
止瀉湯의 抗瀉下作用에 關한 硏究
류인수, 류봉하, 김진성
경희대학교 한의과대학 비계내과학교실
Experimental Studies on the Anti-diarrhea Effects of Jisa-tang
Ihn-soo Ryu, Bong-ha Ryu, Jin-sung Kim
3rd Department of Internal Medicine, College of Oriental Medicine, Kyunghee University
Correspondence  Bong-ha Ryu ,Tel: 02-958-9137, Fax: 02-958-9136, Email: rbongh@khu.ac.kr
  Published online: June 30, 2008.
ABSTRACT
Objective :
The aim of this experimental study was to investigate the anti-diarrhea effects of Jisa-tang using mice and guinea pigs.

Methods :
We feed Jisa-tang to mice and guinea pigs to investigate its effects for anti-diarrhea action. We observed its actions on gastrointestinal smooth muscles, on the transportability of small and large intestines, on diarrhea induced by castor oil and magnesium sulfate, and on enteropooling by castor oil and prostaglandin E2(PGE2).

Results:
1. Jisa-tang showed alleviation, depending on the density, only on the contraction of mice's gastrointestinal smooth muscles induced by histamine. 2. The transportability of the small intestine was not significantly constrained by Jisa-tang. However, the enhancement of pyridostigmine-induced transportability of he small intestine was significantly constrained in the group administered 900mg/kg of Jisa-tang (p<0.05). 3. The transportability of large intestine was significantly constrained in the group administered 1,800mg/kg of Jisa-tang. 4. Jisa-tang showed significant anti-diarrhea effects on diarrhea induced by castor oil and by MgSO4 in the group administered 1,800mg/kg of Jisa-tang. 5. Significant reduction of effects of enteropooling induced by caster oil and by prostaglandin E2 were observed only in the group administered 1,800mg/kg of Jisa-tang.

Conclusions:
We conclude that Jisa-tang has advantageous effects on drug-induced diarrhea and will contribute to the development of diarrhea treatment through further related studies.
Key words: Jisa-tang, Diarrhea, Herb, Oriental Medicine
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