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The Journal of Internal Korean Medicine > Volume 30(1); 2009 > Article
The Journal of Internal Korean Medicine 2009;30(1): 94-106.
元氣生脈散의 추출물별 항산화작용과 쥐의 운동피로 회복효과
김유승, 류봉하, 김진성
경희대학교 한의과대학 비계내과학 교실
Effect of Wongisaengmaek-san Extract on Antioxidative and Anti-Fatigue Activity
Yoo-seung Kim, Bong-ha Ryu, Jin-sung Kim
3rd Department of Internal Medicine, College of Oriental Medicine, Kyung-hee University
Correspondence  Bong-ha Ryu ,Tel: 02-958-9137, Fax: 02-958-9136, Email: rbongh@khu.ac.kr
  Published online: March 30, 2009.
ABSTRACT
Objectives:
This study aimed to evaluate the effect of Wongisaengmaek-san (extracted with water or 50% ethanol) on antioxidative activity and recovery of fatigue induced by weight-loaded forced swimming exercise.

Methods :
Antioxidant activity of Wongisaengmaek-san was evaluated in terms of total amount of polyphenol, 1,1-diphenyl-2-picrylhydroxyl (DPPH) radical scavenging activity and xanthine oxidase inhibition. The anti-fatigue effect of Wongisaengmaek-san was investigated using an acute weight-loaded forced swimming test by monitoring swimming test times and blood biochemical parameters creatinine, BUN, lactic acid dehydrogenase (LDH), free fatty acid (FFA) and lactic acid (LA).

Results:
1. 50% EE (ethanol extract) had 2.3 times higher amount of total polyphenol compared to water extract. 2. It was identified that 50% ethanol extract showed enhancement of xanthine oxidase inhibition and DPPH scavenging effect in vitro. 3. According to anti-fatigue effect in the scale of 5% weight loaded mouse swimming test, both water and 50% ethanol extract showed significant improvement of swimming time elongation respectively, and 50% ethanol extract induced a more positive result. 4. After swimming for 1% weight-loaded mouse, water extract and 50% ethanol showed significant anti-fatigue effect with manifestation of blood sampling among both of the intervention; 50% ethanol extract showed a greater result.

Conclusions:
50% ethanol extract of Wongisaengmaek-san has more effective antioxidant activity and anti-fatigue than water extract.
Key words: Wongisaengmaek-san, Antioxidant, Anti-Fatigue
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