| 降脂通脈飮이 항산화 활성과 高脂血 誘發 白鼠에 미치는 影響 |
| 차관배, 안정조, 조현경, 유호룡, 김윤식, 설인찬 |
| 대전대학교 한의과대학 심계내과학교실 |
| The Effects of Gangzitongmaekeum on Antioxidation Activity and Dietary Hyperlipidemia-induced Mice |
| Kwan-bae Cha, Joung-jo An, Hyun-kyung Jo, Ho-rhyong Yoo, Yoon-sik Kim, In-chan Seol |
| Department of Internal Medicine, College of Oriental Medicine, Daejeon University |
| Correspondence |
In-chan Seol ,Tel: 042-229-6805, Fax: 042-254-3403, Email: seolinch@dju.ac.kr
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Published online: September 30, 2008. |
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| ABSTRACT |
This experiments was performed to determine the effects of Gangzitongmaekeum(降脂通脈飮 : GTE) on antioxidation activity and hyperlipidemia induced by hypercholesterolemic diet in mice. The results obtained were as follows :
1. GTE showed a safety in cytotoxicity and toxicity of human fibroblast cells and liver.
2. GTE showed DPPH scavenging activity, superoxide dismutase (SOD)-like activity and inhibitory effect on reactive
oxygen species (ROS).
3. GTE treated mice showed body and liver weight decrease, compared to the hyperlipidemia-induced control group.
4. GTE decreased total cholesterol and LDL cholesterol levels significantly, but HDL cholesterol levels not significantly.
5. GTE decreased triglyceride levels significantly.
6. Glucose levels in GTE treated mice significantly decreased compared to the hyperlipidemia-induced control group.
7. Albumin levels in GTE treated mice were similar with the hyperlipidemia-induced control group.
8. The lipophagy in liver compared with the control group tended to be decreased in GTE treated mice. In the change of
aorta, the cell was regular and boundary of vessel wall was clear, compared to the hyperlipidemia-induced control group.
9. TBARS levels in GTE treated mice significantly decreased compared to the hyperlipidemia-induced control group.
10. The change of SOD and catalase activity significantly increased compared to the hyperlipidemia-induced control group.
11. ACAT mRNA level and HMG-CoA reductase mRNA levels in GTE treated mice significantly decreased compared to
the hyperlipidemia-induced control group.
Conclusion:
These results suggest that Gangzitongmaekeum is effective in antioxidation activity and dietary
hyperlipidemia-induced mice. |
| Key words:
Hyperlipidemia, Antioxidation Activity, Gangzitongmaekeum |
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