Experimental Studies on the Anti-cathartic Effects of Dolichoris Semen, Terminaliae Fructus and Bojanggunbi-tang

Ro, Wooseong; Ryu, Bongha; Kim, Jinsung; Yoon, Sanghyub

The Journal of Internal Korean Medicine > Volume 27(2); 2006 > Article

Original Article

The Journal of Internal Korean Medicine 2006;27(2): 356-370.

白扁豆, 訶子 및 補腸健脾湯의 抗瀉下作用에 關한 硏究

노우성, 류봉하, 김진성, 윤상협

경희대학교 한의과대학 비계내과학교실

Experimental Studies on the Anti-cathartic Effects of Dolichoris Semen, Terminaliae Fructus and Bojanggunbi-tang

Wooseong Ro, Bongha Ryu, Jinsung Kim, Sanghyub Yoon

3rd Deptartment of Internal Medicine, College of Oriental Medicine, Kyungghee University

Correspondence

Bongha Ryu ,Tel: 02-958-9140, Fax: 02-958-9136, Email: rbongh@khu.ac.kr

Received: May 11, 2006, Accepted: June 13, 2006, Published online: June 30, 2006.

ABSTRACT

Objectives:
The aim of this experimental study is to investigate effects of Dolichoris Semen, Terminaliae Fructus and Bojanggunbi-tangon the anti-cathartic action of mice and guinea pigs to develop effective herbal medicine and prescription to cure diarrhea early and to prevent side effect of chronic diarrhea.

Methods:
To compare effects of Dolichoris Semen, Terminaliae Fructus and Bojanggunbi-tangon the anti-cathartic action of mice and guinea pigs, we evaluated the actions on isolated gastrointestinal smooth muscles, on the transportability of small and large intestines, onthe neostigmine-induced transportability of small intestine and on diarrhea induced by castor oil, pilocarpine, barium chloride.

Results:
(1) Dolichoris Semen, Terminaliae Fructus and Bojanggunbi-tang showed the strong alleviation on the contraction of mice's isolated gastrointestinal smooth muscles induced by acetylcholine chloride and barium chloride, while Terminaliae Fructus, strong, Bojanggunbi-tang, intermediate and Dolichoris Semenshowed the minor alleviation on the contraction of guinea pigs' isolated gastrointestinal smooth muscles induced by acetylcholine chloride and histamine. All effects depended on the density in each medicine. (2) The transportability of small intestine was contrained in the groups controlled by 600 mg/kg of Dolichoris Semen, Terminaliae Fructus and Bojanggunbi-tang, and 200 mg/kg of Dolichoris Semen and Terminaliae Fructus. However, the enhancement of neostigmine-induced transportability of small intestine was constrained only in the groups controlled by 600 mg/kg of Dolichoris Semen, Terminaliae Fructus and Bojanggunbi-tang. (3) The transportability of large intestine was constrained by Dolichoris Semen and Bojanggunbi-tang. They showed substantial results, which depended on the amount of each medicine. (4) Terminaliae Fructus showed substantial anti-cathartic effects on diarrhea induced by castor oil in both groups controlled by 200 and 600 mg/kg of it. However, Bojanggunbi-tangshowed the effects only in the group controlled by 600 mg/kg. In diarrhea induced by pilocarpine, the groups controlled by 600 mg/kg of Terminaliae Fructus and 200 and 600 mg/kg of Bojanggunbi-tangshowed substantial results. In diarrhea induced by barium chloride, the groups controlled by 200 and 600 mg/kg of Terminaliae Fructus and 600 mg/kg of Bojanggunbi-tangshowed substantial results in anti-cathartic effects.

Conclusions:
These results show that Terminaliae Fructus is more effective on the contraction of mice and guinea pigs' isolated gastrointestinal smooth muscles, Dolichoris Semen is more effective on the transportability of small intestine, Dolichoris Semen and Bojanggunbi-tang are more effective on the transportability of large intestine. Terminaliae Fructus and Bojanggunbi-tang show substantial results in anti-cathartic actions.

Key words: Anti-cathartic action, Dolichoris Semen, Terminaliae Fructus, Bojanggunbi-tang