| 三一腎氣丸이 methotrexate로 誘發된 흰쥐의 免疫機能低下에 미치는 影響 |
| 최영아, 박송기, 권은희, 이연경, 신현철, 강석봉 |
| 대구한의대학교 한의과대학 내과학교실 |
| The Effect of Samilshinkihwan on Immunosuppression Induced in Rats by Methotrexate |
| Young-ah Choi, Song-kee Park, Eun-hee Kwon, Yeon-kyeong Lee, Hyeon-cheol Shin, Seok-bong Kang |
| Department of Internal Medicine, College of Oriental Medicine, Dae-Gu Hanny University |
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Published online: March 30, 2007. |
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| ABSTRACT |
Objective :
To investigate the effect of Samilshinkihwan(SISKW) on white rats with deteriorated immunity caused by methotrexate.
Methods :
The test articles were dosed once a day for 14 days by gastric gavage at a dosage 1000, 500 and 250㎎/㎏/10㎖ of SISKW from 2 days after last MTX-dosing, and changes in body weight, spleen weight, total blood leukocyte numbers, total lymphocyte numbers, B and T lymphocyte ratio, CD3+CD4+, CD3+/CD8+ and CD4+/CD8+ T lymphocyte ratio in the blood and spleen were measured. In addition, the serum interleukin (IL)-2 levels and the productivity of IL-2 of splenic cells were also demonstrated in this study.
Results:
The changes on body weight increased significantly in the 1000㎎/㎏of SISKW group. The changes on the spleen weight, the total blood leukocytenumbers, the total lymphocyte numbers in the blood and spleen, the ratio of T-cell in the blood and spleen and the ratio of CD3+CD4+ T-cell in spleen increased significantly in all SISKW groups as compared with the control group. The ratio of CD4+/CD8+ T-cells in blood increased significantly. The serum IL-2 levels and productivity of IL-2 of splenic cells increased significantly in 1000 and 500㎎/㎏ SISKW groups as compared with the control group.
Conclusions:
Samilshinkihwanhas an effect of increasing immune responses, especially on cellular immune responses, in white rats with deteriorated immunity caused by methotrexate. |
| Key words:
Samilshinkihwan(Sanyishenqiwan), Methotrexate, T-cell, CD3+CD4+ T-cell, Immunosuppression |
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