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The Journal of Internal Korean Medicine > Volume 34(1); 2013 > Article
The Journal of Internal Korean Medicine 2013;34(1): 59-70.
온열환경과 부자이중탕(附子理中湯)이 Rat의 면역반응 및 지질대사에 미치는 효과
노현인1, 윤다래1, 이서라1, 이인희1, 홍성인2, 류재환3
1경희대학교 한의과대학 내과학교실
2경희의료원 한방병원 동서협진실
3경희대학교 동서의학대학원 동서의학과
The Effect of Warm Environment and Bujaijung-tang on Immune and Lipid Metabolism in Rats
Hyun-in Noh1, Da-rae Yoon1, Seo-ra Yi1, In-hee Lee1, Sung-in Hong2, Jae-hwan Ryu3
1Dept. of Oriental Internal Medicine, College of Oriental Medicine, Kyung-Hee university
2Dept. of East-west integrated medicine, Kyung-Hee Oriental Medical Hospital
3East-west medicine department, Graduate school of east-west medical science, Kyung-Hee University
Correspondence  Jae-hwan Ryu ,Tel: 02-958-1812, Fax: 02-958-9212, Email: intmed@khu.ac.kr
  Published online: March 30, 2013.
ABSTRACT
Objectives:
This study was designed to test the effect of a warm environment and Bujaijung-tang on immune and lipid metabolism in rats.

Methods :
The extract from Bujaijung-tangBujaijung-tang administration. Each group had 8 Sprague-Dawley Rats. We measured body temperature twice a week, body weight three times a week. After 3 weeks of experiment, serum lipid level, WBC, differential count, lymphocyte proliferation and immune cytokine concentration were measured.

Results:
1. warm environment induced weight loss in rats. 2. warm environment induced a decrease of total cholesterol and low-density lipoprotein (LDL) cholesterol gain. 3. warm environment and Bujaijung-tang induced an increase of tumor necrosis factor (TNF)-α concentration.

Conclusions:
The warm environment had a hyperlipidemia modulating effect. The warm environment and Bujaijung-tang had an immune modulating effect.
Key words: warm environment, Bujaijung-tang, body weight, lipid, immune, TNF-α
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