| 몰약이 Monosodium Urate로 유발된 백서의 통풍에 미치는 영향 |
| 정대호, 장선규, 조충식, 김철중 |
| 대전대학교 한의과대학 신계내과학 교실 |
| Effects of Commiphora Myrrha (CM) on the Monosodium Urate (MSU)-induced Gout Model in Rats. |
| Dae-Ho Jung, Sun-Kyu Chang, Chung-Sik Cho, Cheol-Jung Kim |
| Department of Internal Medicine, College of Oriental Medicine, Daejeon University, Daejon, Korea. |
| Correspondence |
Chung-Sik Cho ,Tel: 041-521-7531, Fax: 041-521-7007, Email: choo1o2@chol.com
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Published online: September 30, 2006. |
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| ABSTRACT |
Objective :
To identify the inhibitory effects of Commiphora Myrrha (CM) on monosodium urate (MSU)-induced gout model in rats.
Materials and Methods :
After pretreatment with CM-Ⅰ(125㎎/㎏) or CM-Ⅱ (50㎎/㎏) for 7 days followed by ones injection of MSU solution, the various indicators related to gout were measured on hematological and serum level including joint inflammation. Also, it was studied whether FBM directly inhibits the activity of xanthine oxidase in vitro.
Results:
As a result of this study, CM didn't show cytotoxicity in Jurkat cells, but it showed significant inhibition of activity of xanthine oxidase in vitro. CM slightly inhibited joint inflammation induced by MSU though not with statistical significance. CM partially decreased MSU-induced albumin, globulin, AST, ALT, BUN, creatinine, WBC, platelet count and ESR level and significantly decreased MSU-induced uric acid in serum.
Conclusion:
These results suggest that CM has therapeutic effects that are applicable to prevention and treatment of gout, and should be further investigated. |
| Key words:
Gout, Commiphora Myrrha(CM), Monosodium Urate(MSU), xanthine oxidase(XO). |
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