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The Journal of Internal Korean Medicine > Volume 29(4); 2008 > Article
The Journal of Internal Korean Medicine 2008;29(4): 922-938.
紅景天추출물(KH101)이 강제유영 흰쥐의 피로회복에 미치는 영향
정혁상1, 김은영1, 심은섭1, 이현삼1, 문은정2, 김진화4, 김선여2, 손영주3, 손낙원2
1경희대학교 한의과대학, 한의학연구소
2경희대학교 동서의학대학원
3상지대학교 한의과대학
4(주)경희매니지먼트컴퍼니
Effects of Rhodiola rosea (KH101) on Anti-fatigue in Forced Swimming Rats
Hyuk-sang Jung1, Eun-young Kim1, Eun-sheb Shim1, Hyun-sam Lee1, Eun-jung Moon2, Zhen-hua Jin4, Sun-yeou Kim2, Young-joo Sohn3, Nak-won Sohn2
1College of Oriental Medicine, Institute of Oriental Medicine, Kyung Hee University
2Graduate School of East-West Medical Science, Kyung Hee University
3College of Oriental Medicine, Sangji University,
4Kyung Hee Management Compeny
Correspondence  Nak-won Sohn ,Tel: 031-201-2747, Fax: 031-204-6832, Email: sohnnw@khu.ac.kr
  Published online: December 30, 2008.
ABSTRACT
Objectives:
Rhodiola rosea has been used in herbal medicine to treat various conditions, such as antimelancholia, antifatigue, improvement of work competence and prevention of altitude sickness. In this study, we investigated effects of Rhodiola rosea extract (KH101) on fatigue in forced swimming rats.

Methods :
Sprague-Dawley rats were induced with fatigue by forced swimming, then rats in each group were treated with KH101. We observed changes of glucose, LDH and cortisol in serum and LDH, glycogen, hexokinase, citrate synthase MDH, SDH and CK in muscle.

Results:
Obtained results were as follows; 1. Continuance times of exercise significantly increased in all groups at day 1, in the 50 mg/kg concentration group at day 2, in all groups at day 3 and in the 50 mg/kg conc. group at day 4. 2. In serum, glucose significantly decreased in all concentration groups. 3. In the soleus muscle, LDH significantly decreased in the 50 mg/kg concentration group. HK significantly decreased in the 100 mg/kg conc. group. SDH significantly increased in the 100 mg/kg conc. MDH were significantly decreased in all conc. groups. 4. In the gastrocnemius muscle, HK significantly decreased in all concentration groups, while MDH significantly increased all conc. groups.

Conclusions:
It is concluded that the KH101 has and anti-fatigue effect in rats. Additional studies are needed to find the mechanism of the association between each single herb.
Key words: Forced Swimming, antifatigue, Rhodiola rosea extract, Soleus muscle, Gastrocnemius muscle
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