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The Journal of Internal Korean Medicine > Volume 28(1); 2007 > Article
Original Article
The Journal of Internal Korean Medicine 2007;28(1): 133-148.
茵蔯淸肝湯이 DMN에 의한 간손상 proteome에 미치는 영향
김효진, 김영철, 이장훈, 우홍정
경희대학교 한의과대학 간계내과학교실
The Effects of Injinchunggan-tang (Yinchenchinggan-tang) on DMN Liver Damage from Applying Proteomics
Hyo-jin Kim, Young-chul Kim, Jang-hoon Lee, Hong-jung Woo
Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University
Correspondence  Hong-jung Woo ,Tel: 02-958-9118, Fax: 02-958-9120, Email: hjwoo@khu.ac.kr
  Published online: March 30, 2007.
ABSTRACT
Objectives:
The purpose of our study was to investigate the effects of Injinchunggan-tang (Yinchenchinggan-tang) on DMN liver damage caused by applying proteomics. Materials and

Methods:
Sprague-Dawley rats were used in this experiment; the rats were divided into the normal group (normal saline), the control group (DMN) and the samplegroup (DMN+IJCGT). The DMN was induced 3 days a week for 3 weeks in the control group. The normal saline without DMN was induced by the same method in the normal group. Injinchunggan-tang extract was orally administered twice a day for 3 weeks after DMN was induced in the sample group. The livers of each group were processed and we investigated histology, OxyBlot, 2-dimensional electrophoresis, and western blot of liver of each group.

Results:
In the histological findings of the liver, the control group showed portal fibrosis with a few septa or without septa. The sample group showed no fibrosis or portal fibrosis without septa. In the OxyBlot finding, Injinchunggan-tang prevented liver damage by oxidation. In the 2-dimensional electrophoresis finding, formiminotransferase cyclodeaminase (FTCD), FYVE-finger containing protein, aldehyde dehydrogenase (ALDH), and ratio of predicted : hypothetical protein LOC68668 isoform 1 were changed.

Conclusions:
Injinchunggan-tang exerts an inhibitory effect against the fibrosis and oxidation induced by the DMN in the rat liver cell, and some proteins induced by the DMN were changed by Injinchunggan-tang.
Key words: Injinchunggan-tang, Proteomics, DMN liver damage
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